Faculty Descriptions and Representative Publications

Faculty: Patricia Areán, Ph.D.
Patricia Areán, Ph.D. is an Associate Professor in the Department of Psychiatry. Dr. Areán is a Clinical Psychologist, health services researcher, and an internationally recognized expert in effectiveness of psychotherapy for the treatment of mental disorders in older adults and minorities. She is a member of the NIMH study section for services research in specialty settings. Her research is funded by NIMH, Hartford Foundation, California Health Care Foundation, NIA and SAMHSA and includes treatment effectiveness, access research on mental health and substance abuse in older and minority populations. The fellows she has mentored have largely gone on to academic positions.

Areán PA, Ayalon L, Hunkeler EM, Tang L, Unutzer J, Lin E, Harpole L, Williams J, Hendrie H. (2005). Improving depression care in older, minority primary care patients. Medical Care, 43: 381-390.

Areán PA, Reynolds CF III. (2005). Psychosocial risk factors in late life depression. Biological Psychiatry, 58: 277-282.

Feldman MD, Arean PA, Ong MK, Lee DL, Feldman S. (2005). Creating incentives for primary care providers to refer patients to a collaborative care program for depression. Psychiatric Services, 56(11), 1- 3.

Hegel MT, Unutzer J, Tang L, Areán PA, Katon W, Noel PH, Williams JW, Lin EH. (2005). Impact of comorbid panic and post traumatic stress disorder on outcomes of collaborative care for late-life depression in primary care. American Journal of Geriatric Psychiatry, 13: 48-58.

Satre D, Areán PA. (2005). Effects of gender, ethnicity, and medical illness on drinking cessation in older primary care patients. Journal of Aging and Health, 17, 71-84.

Faculty: William Byerley, M.D.
William Byerley, M.D. is a Professor in Residence of Psychiatry at UCSF and Director of the Neurogenetics Substance Abuse Program at the San Francisco VAMC. His research focuses on gene mapping studies of neuropyschiatric disorders. He has received continuous R01 type funding by NIH since 1988 for genetic studies. His current work is supported by three NIH grants. Dr. Byerley was early leader in using genetic isolates for gene mapping studies and he continues to devote considerable efforts on these special populations. Dr. Byerley’s main molecular genetics laboratory is located at the Langley Porter Psychiatric Institute. Dr. Byerley is the recipient of a distinguished teaching award from UCSD. He is a member of the American College of Neuropsychopharmacology (ANCP) and is on the scientific advisory board of the National Alliance for Research on Schizophrenia and Depression (NARSAD). He has mentored over 20 undergraduates, graduate students, postdocs, psychiatry residents and junior faculty members. Short term (2 to 3 months) and long term projects can be carried out in his laboratory. He is particularly interested in the genetics of nicotine, marijuana and opiate dependence. Phenotyping, genotyping and data analysis projects are possible for postdoctoral trainees, depending on the trainee’s interests and expertise.

Cooper KC, Mesen A, Galke B, Delisi L, Byerley W. (2005). Suggestive linkage of schizophrenia to 5p13 in Costa Rica. Molecular Psychiatry, 10(7):651-6.

Klei L, Bacanu SA, Myles-Worsley M, Galke B, Xie W, Tiobech J, Otto C, Roeder K, Devlin B, Byerley W. (2005). Linkage analysis of a completely ascertained sample of familial schizophrenics and bipolars from Palau, Micronesia. Human Genetics, 117(4), 349-56.

Devlin B, Bacanu SA, Roeder K, Reimherr F, Wender P, Galke B, Novasad D, Chu A, TCuenco K, Tiobek S, Otto C, Byerley W. (2002). Genome-wide multipoint linkage analyses of multiplex schizophrenia pedigrees from the oceanic nation of Palau. Molecular Psychiatry, 7:689–694.

Faculty: Timothy Carmody, Ph.D.
Timothy Carmody, Ph.D. is a Clinical Professor in the Department of Psychiatry, University of California, San Francisco, Director of the Health Psychology Program, and Director of Primary Care Psychology Training Programs at the San Francisco Veterans Affairs Medical Center. Dr. Carmody received his doctorate in clinical psychology from the University of Montana in 1977. For eight years, he was a faculty member in the Department of Medical Psychology at the Oregon Health Sciences University. His primary research interests include smoking cessation, pain management, behavioral factors in coronary disease prevention, and obesity/weight control. His research has been funded through the VA Health Services Research and Development Program and University of California Tobacco-Related Disease Research Program (TRDRP) for conducting clinical trials in smoking cessation. He is active as a teacher and mentor in the SFVAMC pre-doctoral APA-approved clinical internship training program. He serves as a consultant to the VA’s Office of Research and Cooperative Studies Program and is a member of the VA Smoking Cessation Technical Advisory Group for the Public Health and Prevention Office at VA Headquarters. He has been the recipient of a Research Career Development Award from the National Heart Lung and Blood Institute (NHLBI) and has served on several ad hoc grant review committees for NHLBI. He serves on the editorial board of the Journal of Clinical Psychology in Medical Settings and is an editorial consultant to several other professional journals. He is currently a TRC component PI for a clinical trial investigating an intensive smoking cessation intervention for alcohol-dependent smokers in early recovery. Trainees working with Dr. Carmody have an opportunity to participate in secondary data analysis projects examining research questions related to smoking cessation treatment and assist the Smoking Cessation Research Group at the SFVAMC with data management and data collection activities related to ongoing clinical trials.

Key words: tobacco use disorder, chronic pain, cognitive behavior therapy, obesity/weight control

Tong, E.K., Carmody, T.P., & Simon, J.A. (2006) Bupropion for smoking cessation: A review. Comprehensive Therapy, 32(1), 26-33.

Simon, J.A., Duncan, C., Carmody, T.P., & Hudes, E.S. (2004). Bupropion for smoking cessation: A randomized trial. Archives of Internal Medicine, 164, 1797-1803.

Simon, J.A., Carmody, T.P., Hudes, E.S., Snyder, E., & Murray, J. (2003). Intensive smoking cessation counseling versus minimal counseling among hospitalized smokers on transdermal nicotine replacement: A randomized trial. American Journal of Medicine, 114, 555-562.

Carmody, T.P. (2002). Smoking cessation treatment groups. In R. Brook & H. Spitz (Eds.), Group Psychotherapy for Substance Abuse, American Psychiatric Association.

Carmody, T.P. (2001). Psychosocial subgroups, coping, and chronic low back pain. Journal of Clinical Psychology in Medical Settings, 8, 137-148.

Faculty: Gary Humfleet, Ph.D.
Gary Humfleet, Ph.D. is an Associate Clinical Professor and the Clinical Director of the Habit Abatement Clinic, where approximately 250 smokers participate in clinical trials each year. Dr. Humfleet’s research and clinical work at UCSF focuses on the efficacy of clinical interventions for nicotine dependence, factors predictive of smoking treatment success, and development of Internet-based interventions for health behavior change. His work currently focuses on nicotine dependence and smoking cessation in special populations. He has a NIDA-funded project evaluating the efficacy of Internet-based smoking treatment for lesbian, gay, bisexual, and transgender (LGBT) cigarette smokers. As a part of the UCSF Treatment Research Center, Dr. Humfleet leads a study evaluating the efficacy and cost-effectiveness of smoking treatment provided in HIV clinical care settings. Other work has focused on the efficacy of mood management techniques in smoking treatment, the use of nortriptyline as an adjunct to psychosocial counseling, and the development of smoking treatment based on a conceptualization of nicotine dependence as a chronic, relapsing disorder. He is also interested in the impact of alcohol and drug use on smoking cessation outcomes. As a faculty member, he works closely with scholars interested in nicotine dependence, serves as a mentor to postdoctoral fellows, and co-teaches the Substance Abuse Seminar and Lecture Series each year.

Key words: smoking, nicotine dependence, gay, lesbian, bisexual, transgender, HIV, computer, Internet, special populations, clinical trials

Humfleet G, Prochaska J, Mengis M, Cullen J, Munoz R, Reus V, & Hall S. (2005). Preliminary evidence of the association between the history of childhood attention deficit hyperactivity disorder and smoking treatment failure. Nicotine and Tobacco Research, 7, 453-460.

Haug NA, Hall SM, Prochaska JJ, Rosen AB, Tsoh JY, Humfleet GL, Delucchi K, Rossi JS, & Redding CA. (2005). Acceptance of nicotine dependence treatment in a psychiatric outpatient clinic: Smokers with depressive disorders. Nicotine and Tobacco Research, 7, 217-224.

Humfleet GL & Haas AL. (2004). Is marijuana use becoming a “gateway” to nicotine dependence? Addiction, 99(1), 5-6.

Haas AL, Muñoz RF, Humfleet GL, Reus VI, & Hall SM. (2004). Influences of mood, depression history, and treatment modality on outcomes in smoking cessation. Journal of Consulting and Clinical Psychology, 72, 563-570.

Prochaska JJ, Rossi JS, Redding CA, Rosen AB, Tsoh JY, Humfleet GL, Eisendrath SJ, Meisner MR, & Hall SM. (2004). Depressed smokers and stage of change: Implications for treatment interventions. Drug and Alcohol Dependence, 76, 143-151.

Faculty: Carmen Masson, Ph.D.
Carmen Masson, Ph.D. is an Assistant Adjunct Professor in the Department of Psychiatry at UCSF. Dr. Masson’s research focuses on two related areas: HIV prevention among substance users (e.g., out-of-treatment injection drug users, HCV infected methadone patients, and substance users with co-occurring severe mental illness) and health services research. Through randomized controlled trial methods, her research program focuses on the evaluation of interventions that are designed to improve access and delivery of prevention and health care services for substance using populations. This research also addresses the impact of service delivery characteristics on HIV risk behaviors and other health outcomes. Currently she has three funded projects including a study that tests the feasibility of implementing a depression case management intervention for stimulant users seeking medical care at a public hospital; a randomized clinical trial that examines the effectiveness of a strategy of HIV and hepatitis care coordination compared with standard HIV/hepatitis testing, education, and counseling in a methadone treatment setting; and a randomized clinical trial that tests the effectiveness of an HIV prevention case management intervention versus standard HIV education and counseling for substance users with severe mental illness. Dr. Masson is affiliated with the California-Arizona Node of the NIDA Clinical Trials Network, a network of scientists and clinicians dedicated to improving the quality of substance abuse treatments through multi-site clinical trials research. She has participated as a faculty member in the NIDA-funded Postdoctoral Program in Drug Abuse Treatment and Services Research at UCSF since 1998. Dr. Masson also participates in the UCSF Department of Psychiatry Summer Research Training Program.

Key words: HIV and HCV prevention, injection drug users, health services, stimulant users, co-occurring disorders, depression, methadone patients, severe mental illness

Barnett PG, Masson CL, Sorensen JL, Wong W, Delucchi K, & Hall S. (In press). Linking opioid dependent emergency patients to drug treatment: Health care use and costs 6 months after randomization. Addiction.

Masson, CL, Sorensen, JL, Perlman, DC, Shopshire, MS, Delucchi, KL, Chen, T, Sporer, K, Des Jarlais, D, & Hall, SM. (In press). Hospital versus community-based syringe exchange: A randomized controlled trial. AIDS Education and Prevention.

Wasserman, D. A., Sorensen, J. L., Delucchi, K. L., Masson, C. L., & Hall, S.M. (2006). Psychometric evaluation of the quality of life interview, brief version in a sample of opioid users. Psychology of Addictive Behaviors, 20(3), 316-321.

Carey J, Perlman DC, Friedmann P, Nugent A, Deutscher M, Masson CL, & Des Jarlais D. (2005). Knowledge of hepatitis among active drug injectors at a syringe exchange program. Journal of Substance Abuse Treatment, 29: 47-53.

Sorensen JL, Masson CL, Delucchi K, Sporer K, Barnett PG, Mitsuishi F, Lin C, Song Y, Chen T, Hall SM. (2005). Randomized trial of drug abuse treatment-linkage strategies. Journal of Consulting and Clinical Psychology, 73(6), 1026-1053.

Faculty: Carol A. Matthews, M.D.
Carol A. Mathews, M.D., is an Associate Professor in the Department of Psychiatry. Her research focuses on the phenomenology, epidemiology, and genetics of neuropsychiatric symptoms and disorders, including obsessive-compulsive disorder (OCD), Tourette Syndrome (TS) and attention deficit hyperactivity disorder (ADHD). Her research is funded by NINDS, NIMH, NARSAD, the Obsessive Compulsive Foundation, and the Tourette Syndrome Association, and includes genetic studies of OCD, TS, and ADHD in Costa Rica and the US, studies of potential environmental factors that predispose or worsen neuropsychiatric symptoms (including prenatal maternal nicotine, drug, and alcohol use) and epidemiological studies of neuropsychiatric symptoms in non-clinical populations and relatives of individuals with neuropsychiatric disorders. She is also interested in the comorbidity and common etiological factors underlying anxiety disorders and substance abuse. Research opportunities in her lab include translational research into comorbid substance use and anxiety and impulse control disorders, including, but not limited to, genetic and epidemiological studies, and studies of environmental risk factors predisposing to these disorders.

Mathews CA, Bimson B, Lowe TL, Herrera LD, Budman CL, Erenberg G, Naarden A, Bruun RD, Freimer NB, Reus VI (2006). Association between maternal smoking and increased symptom severity in Tourette Syndrome. American Journal of Psychiatry, 163:1066-1073.

Abelson JF, Kwan KY, O'roak BJ, Baek DY, Stillman AA, Morgan TM, Mathews CA, Pauls DL, Rasin MR, Gunel M, Davis NR, Ercan-Sencicek AG, Guez DH, Spertus JA, Leckman JF, Dure LS 4th, Kurlan R, Singer HS, Gilbert DL, Farhi A, Louvi A, Lifton RP, Sestan N, State MW (2005). Sequence variants in SLITRK1 are associated with Tourette's Syndrome. Science, 310:317-320.

Mathews CA, Jang K, Hami S, Stein MB (2004). The structure of obsessionality in young adults. Depression and Anxiety, 20:77-85.

Mathews CA, Reus VI, Bejarano J, Escamilla ME, Fournier E, Herrera LD, Lowe TL, McInnes LA, Molina J, Ophoff RA, Raventos H, Sandkuijl LA, Service SK, Spesny S, León PE, Freimer NB (2004). Genetic studies of neuropsychiatric disorders in central america. Psychiatric Genetics, 14:13-23.

Escamilla MA, Batki SL, Reus VI, Spesny M, Molina J, Service S, Vinogradov S, Neylan T, Mathews C, Meza L, Gallegos A, Montero AP, Cruz ML, Neuhaus J, Roche E, Smith L, Leon P, Freimer NB. (2002). Comorbidity of bipolar disorder and substance abuse in a Latin American population: Pedigree and population based studies. Journal of Affective Disorders, 71:71-83.

Faculty: Dale E. McNiel, Ph.D.
Dale E. McNiel, Ph.D. is a Professor of Clinical Psychology in the Department of Psychiatry and Chief Psychologist at Langley Porter Psychiatric Hospital and Clinics. His research interests focus primarily on violence and mental disorder, including the role of co-occurring substance abuse and mental disorder in violence and trauma. Projects include improvement of methods for assessment and management of violence risk, interactions between legal and health systems in the treatment of violent patients, mental health courts, and family violence and victims of violence. Dr. McNiel has over 20 years of teaching experience and has served as a research preceptor for many postdoctoral fellows, most of whom have gone on to academic positions. Fellows begin by collaborating on ongoing projects, and develop an empirical project for which they take primary responsibility that is completed by the end of the fellowship. Projects may include secondary analysis of existing data or new data collection in the topics described above. Interested fellows may take elective didactics in forensic mental health services research in conjunction with the UCSF Program on Psychiatry and the Law.

Key words: violence, trauma, mental disorder, substance abuse, co-occurring disorders, services research, forensic psychology

McNiel, D.E., Binder, R.L., & Robinson, J. (2005). Incarceration associated with homelessness, mental disorder, and co-occurring substance related disorders. Psychiatric Services, 56, 840- 846.

McNiel, D.E., & Binder, R.L. (2005). Psychiatric emergency service use associated with homelessness, mental disorder, and violence. Psychiatric Services, 56, 699-704.

Monahan, J., Redlich, A.D., Swanson, J., Robbins, P.C., Appelbaum, P.S., Petrila, J., Steadman, H.J., Swartz, M., Angell, B., & McNiel, D.E. (2005). Use of leverage to improve adherence to psychiatric treatment in the community. Psychiatric Services, 56, 37- 44.

McNiel, D.E., Gregory, A.L., Lam, J.N., Binder, R.L., & Sullivan, G.R. (2003). Utility of decision support tools for assessing acute risk of violence. Journal of Consulting and Clinical Psychology, 71, 945-953.

McNiel D.E., Eisner J.P., & Binder R.L. (2003). The relationship between aggressive attributional style and violence by psychiatric patients. Journal of Consulting and Clinical Psychology, 71, 399-403.

Faculty: Ricardo Muñoz, Ph.D.
Ricardo Muñoz, Ph.D. is Professor of Psychology in the Department of Psychiatry where he serves as Director of the Clinical Psychology Training Program, Chief Psychologist at San Francisco General Hospital (SFGH), and Director of the UCSF/SFGH Latino Mental Health Research Program. His research program is focused on the development and evaluation of methods to screen for, prevent, and treat major depression. He uses a social learning orientation and cognitive-behavioral self-control approaches, and includes Spanish- and English-speaking populations in his work. He was the founding Director of the SFGH Depression Clinic. He has published over 60 articles and chapters, and co-authored or edited five books. His current project is the “Internet Health Research Center: Smoking, Latinos, & the Web,” a bilingual site using randomized control trial methodology conducted via the World Wide Web which tests various smoking cessation approaches. Dr. Munoz welcomes bilingual and biliterate Spanish-speaking postdoctoral trainees with cognitive-behavioral intervention expertise in smoking, depression, or ideally, both. Preferred additional skills include randomized trial methodology, internet-based research, good data analytical ability, and strong interest in reaching underserved populations worldwide with smoking cessation interventions. See http://www.apa.org/monitor/feb02/reaching.html for more information about Dr. Munoz’s laboratory.

Key words: Spanish-speaking, Latinos, depression, smoking, internet research

Muñoz RF, Lenert LL, Delucchi K, Stoddard J, Pérez JE, Penilla C, Pérez-Stable EJ. (2006). Toward evidence-based Internet interventions: A Spanish/English Web site for international smoking cessation trials. Nicotine & Tobacco Research, 8, 77-87.

Muñoz RF & Mendelson T (2005). Toward evidence-based interventions for diverse populations: The San Francisco General Hospital prevention and treatment manuals. Journal of Consulting and Clinical Psychology, 73, 790-799.

Haas AL, Muñoz RF, Humfleet GL, Reus VI, & Hall SM. (2004). Influences of mood, depression history, and treatment modality on outcomes in smoking cessation. Journal of Consulting and Clinical Psychology, 72, 563-570.

Hollon SD, Muñoz RF, Barlow DH, Beardslee WR, Bell CC, Bernal G, Clarke GN, Franciosi LP, Kazdin AE, Kohn L, Linehan MM, Markowitz JC, Miklowitz DJ, Persons JB, Niederehe G, & Sommers D. (2002). Psychosocial intervention development for the prevention and treatment of depression: Promoting innovation and increasing access. Biological Psychiatry, 52, 610-630.

Tsoh JY, Humfleet GL, Muñoz RF, Reus VI, Hartz DT, Hall SM. (2000). Development of major depression after treatment for smoking cessation. American Journal of Psychiatry, 157, 368-374.

Faculty: Judith Prochaska, Ph.D., M.P.H.
Judith Prochaska, Ph.D., M.P.H. is an Assistant Adjunct Professor in the UCSF Department of Psychiatry. Her research focuses on developing effective treatments for tobacco dependence and other leading health risk factors with a specific focus on populations with co-occurring disorders. Current studies include: (1) a NIDA-funded K23 career development award to evaluate extended treatment for tobacco dependence initiated in an inpatient psychiatric setting; (2) a TRDRP-funded study to develop and evaluate a tobacco cessation curriculum for psychiatry residency training programs; (3) a UCSF-funded curriculum innovation grant to improve tobacco-related training for medical students; and (4) investigation of a physical activity intervention for supporting smoking cessation through stress reduction, mood enhancement, and weight control, part of Dr. Sharon Hall’s two NIDA-funded trials. Dr. Prochaska collaborates closely with Drs. Sharon Hall and Janice Tsoh as well as others, and is open to serving as a co-mentor for prospective postdoctoral fellows.

Key words: comorbidity, tobacco, nicotine, treatment, mentally ill, multiple behavioral risks

Prochaska JJ, Fromont SC, Louie AK, Jacobs MH, & Hall SM. (2006). Training in tobacco treatments in psychiatry: A national survey of psychiatry residency training directors. Academic Psychiatry, 30(5), 372-378.

Prochaska JJ, Velicer WF, Prochaska JO, Delucchi K, & Hall SM. (2006). Comparing intervention outcomes in smokers treated for single versus multiple behavioral risks. Health Psychology, 25, 380-388.

Prochaska JJ, Fletcher L, Hall SE, & Hall SM. (2006). Return to smoking following a smoke-free psychiatric hospitalization. The American Journal on Addictions, 15, 15-22.

Prochaska JJ, Delucchi K, & Hall SM. (2004). A meta-analysis of smoking cessation interventions with individuals in substance abuse treatment or recovery. Journal of Consulting and Clinical Psychology, 72, 1144-1156.

Prochaska JJ, Rossi JS, Redding CA, Rosen AB, Tsoh JY, Humfleet GL, Eisendrath SJ, Meisner MR & Hall SM (2004). Depressed smokers and stage of change: Implications for treatment interventions. Drug and Alcohol Dependence, 76, 143-151.

Faculty: Victor I. Reus, M.D.
Victor Reus, M.D. is a Professor in the Department of Psychiatry. Dr. Reus’ main scientific interests lie in the genetics of mood disorders and substance dependence, and unraveling issues of comorbidity. He also has had a longstanding interest in the specific role of glucocorticoids and neurosteroids in the mediation of vulnerability to dependence and mood disorders, and the therapeutic role of antidepressant medication in the treatment of substance dependence. He has served as a mentor for several fellows, including Sidney Frederick, Ph.D., several recent K-award training award recipients (Deborah Harris, M.D., Alison McInnes, M.D., Jodi Prochaska, Ph.D., and Carrie Bearden, Ph.D.), as well as recent fellow, Amin Azzam, M.D. Trainees in Dr. Reus’ laboratory would work on the genetics of smoking dependence and response to therapeutic intervention.

Key words: Psychopharmacology, genetics, stress, hormones, cortisol smoking

Mathews, C.A., Bimson, B., Lowe, T.L., Herrera, L.D., Budman, C.L., Erenberg, G., Naarden, A., Bruun, R.D., Freimer, N.B., Reus, V.I. (2006). Association between maternal smoking and increased symptom severity in Tourette's syndrome. American Journal of Psychiatry, 163(6), 1066-73.

Harris, D.S., Reus, V.I., Wolkowitz, O., Jacob, P. 3rd, Everhart, E.T., Wilson, M., Mendelson, J.E., Jones, R.T. (2006). Catecholamine response to methamphetamine is related to glucocorticoid levels but not to pleasurable subjective response. Pharmacopsychiatry, 39(3):100-8.

Harris DS, Reus VI, Wolkowitz OM, Mendelson JE, Jones RT. (2005). Repeated psychological stress testing in stimulant-dependent patients. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 29(5):669-77.

Bearden CE, Reus VI, Freimer NB. (2004). Why genetic investigation of psychiatric disorders is so difficult. Current Opinion in Genetics & Development, 14(3):280-6.

Hall, S.M., Humfleet, G.L., Reus, V.I., Muñoz, R.F., Cullen, J. (2004). Extended nortriptyline and psychological treatment for cigarette smoking. American Journal of Psychiatry, 161(11), 2100-2107.

Faculty: Derek Satre, Ph.D.
Derek Satre, Ph.D. is an Assistant Adjunct Professor in the UCSF Department of Psychiatry. Dr. Satre’s research is primarily focused on addiction and mental health services. He works closely with the Drug and Alcohol Research Team at the Kaiser Division of Research, directed by Dr. Constance Weisner. In collaboration with this research team, he has investigated age differences in outcomes of patients in the Kaiser Permanente chemical dependency recovery programs, including studies of gender differences and long-term treatment outcomes. He is currently developing a treatment program for older adults in outpatient chemical dependency treatment at Kaiser Permanente, funded by a K23 Career Development Award from NIAAA. He is also interested in treatment for individuals with comorbid chemical dependency and mood disorders, and is involved in a study screening for alcohol and drug problems among psychiatric outpatients at UCSF. Dr. Satre works closely with Dr. Connie Weisner and is open to serving as a co-mentor to postdoctoral fellows.

Satre, D.D. & Areán, P.A. (2005). Effects of Gender, Ethnicity, and Medical Illness on Drinking Cessation in Older Primary Care Patients, Journal of Aging and Health, 17, 70-84.

Satre, D.D. , Mertens, J.R., Areán, P.A, & Weisner, C. (2004). Five-year alcohol and drug treatment outcomes of older adults versus middle-aged and younger adults in a managed care program. Addiction, 99, 1286-1297.

Satre, D. D. , Mertens, J. R., & Weisner, C. (2004). Gender differences in older adult treatment outcomes for alcohol dependence. Journal of Studies on Alcohol, 65, 638-642.

Satre, D.D. , Knight, B.G., Dickson-Furhmann, E., & Jarvik, L.F. (2004). Substance abuse treatment initiation among older adults in the GET SMART program: Effects of depression and cognitive status. Aging and Mental Health, 8, 346-354.

Satre, D.D. , Mertens, J.M., Areán, P.A., & Weisner, C. (2003). Contrasting outcomes of older versus middle-aged and younger adult chemical dependency patients in a managed care program. Journal of Studies on Alcohol, 64, 520-530.

Faculty: Laurence Tecott, M.D., Ph.D.
Laurence Tecott, M.D., Ph.D. is a Professor in the Department of Psychiatry at UCSF. He is also the Associate Director for both the UCSF Center for Neurobiology and Psychiatry and the UCSF Institute for Neurodegenerative Diseases. His laboratory employs mouse molecular genetic methods to examine interactions between genetic and environmental factors in the determination of complex behavioral traits. Because brain serotonin pathways regulate many mammalian physiological and behavioral phenomena, a primary focus is on gene products that contribute to this signaling system. To shed light on the mechanisms through which serotonin regulates neurobehavioral processes such as affect, ingestive behavior and reward, lines of mice with selective mutations of serotonin receptor genes are generated and examined in a multidisciplinary manner. This includes novel approaches for the quantitative assessment and computational modeling of behavioral patterns in mice for a sensitive readout of the impact of genes, drugs and environment on the neural mechanisms regulating complex behaviors. Research opportunities exist in Dr. Tecott's laboratory for basic science projects relating to brain and genetic mechanisms that underlie motivated behaviors, such as overindulgence in food or drugs of abuse.

Bonasera SJ, Chu HM, Brennan TJ, Tecott LH. (2006). A null mutation of the serotonin 6 receptor alters acute responses to ethanol. Neuropsychopharmacology, 31(8):1801-13.

Smart LS and Tecott LH. (2005). Monoamine neurotransmitters. In: Comprehensive Textbook of Psychiatry. Sadock BJ and Sadock VA (Eds.), Lippincott Williams & Wilkins.

Tecott LH. (2005). Transgenic Models of Behavior. In: Comprehensive Textbook of Psychiatry. Sadock BJ and Sadock VA (Eds.), Lippincott Williams & Wilkins.

Cremers TI, Giorgetti M, Bosker FJ, Hogg S, Honig G, Bogeso KP, Westerink BH, Boer JA, Wikstrom HV and Tecott LH. (2004). Inactivation of 5-HT(2C) receptors potentiates consequences of serotonin reuptake blockade. Neuropsychopharmacology, 29(10):1782-9.

Cannon, CM, Abdallah L, Tecott LH, During MJ, Palmiter RD. (2004). Dysregulation of striatal dopamine signaling by amphetamine inhibits feeding by hungry mice. Neuron, 44(3):509-20.

Faculty: Janice Tsoh, Ph.D.
Janice Tsoh, Ph.D. is an Assistant Adjunct Professor in the Department of Psychiatry. She is a clinical psychologist specialized in behavioral medicine and health psychology. Dr. Tsoh is a Principal Investigator on three studies: "Expert System and Family Assisted Interventions for Chinese Smokers" funded by the American Cancer Society, a development trial examining a stepped-care smoking model for patients in substance abuse outpatient treatment setting funded by NIDA, and "A Stage-Matched Scheduled Smoking Intervention for Chinese" funded by the California Tobaccor Related Disease Research Program. Her research program focus on nicotine dependence and smoking cessation treatment in special populations: 1) researching effective channels for delivering smoking cessation treatment; 2) developing comprehensive and cultural sensitive treatment approaches using a combination of pharmacological and psychological interventions; and 3) disseminating intervention technology from research to the community.

Key words: nicotine dependence, smoking cessation, health promotion, disease prevention, cancer prevention, health disparities, depression, substance abuse, cross-cultural psychology, minority health

Schmitt EM, Tsoh JY, Dowling GA, Hall SM. (2005). Older adults' and case managers' perceptions of smoking and smoking cessation. Journal of Aging and Health, 17(6):717-33.

Tsoh, J.Y. & Hall, S.M. (2004). Depression and smoking: from the Transtheoretical Model of change perspective. Addictive Behaviors, 29, 801-805.

Tsoh, J.Y., Lam, J.N., Delucchi, K., & Hall, S.M. (2003). Smoking and Depression in Chinese Americans. The American Journal of Medical Sciences, 326, 187-191.

Kohn, C.S., Tsoh, J.Y., & Weisner, C.M. (2003). Smoking Status Among Substance Abusers: Baseline Characteristics and Association with Treatment Outcomes at 12-Months. Drug and Alcohol Dependence, 69, 61-71.

Prochaska, J.O., Velicer, W.F., Fava, J.L., Rossi, J.S., & Tsoh, J.Y. (2001). A stage-matched expert system intervention for a total population of smokers. Addictive Behaviors. 26I, 583-602.

Faculty: Sophia Vinogradov, M.D.
Sophia Vinogradov, M.D. is a Professor in Residence of Psychiatry at the Department of Psychiatry at UCSF and Director of Research and Education for the Mental Health Service at the San Francisco Department of Veterans Affairs Medical Center. Her clinical research program at the SFVAMC involves a multivariate study of schizophrenia with an emphasis on pathophysiology and cognitive neuroscience. Her main focus is on the cognitive abnormalities associated with chronic psychosis and on their relationship to psychopathology as well as to neuroimaging findings (in collaboration with Ray Deicken at the SFVAMC and Gregory Simpson in the Department of Radiology). Her laboratory has developed specific interests in the issue of neurocognitive heterogeneity in schizophrenia, in the relationship between cognitive functioning and substance abuse in schizophrenia, in cognitive training techniques relevant to schizophrenia, and in developmental abnormalities associated with the risk for schizophrenia, including substance use (in collaboration with Alan Brown at Columbia University). Dr. Vinogradov is an experienced mentor, and has worked with both psychology and psychiatry postdoctoral fellows in this and other postdoctoral training programs. She is active in the teaching mission of the medical school and has received numerous teaching awards for her lectures and seminars, including election to the San Francisco chapter of the Alpha Omega Alpha Honor Society. Trainees should have strong interests in severe mental illness and cognitive functioning and in translational approaches to behavioral disorders.

Key words: schizophrenia, cognitive remediation, early intervention

Vinogradov S, Luks TL, Simpson GV, Schulman BJ, Glenn S, Wong AE. (2006). Brain activation patterns during memory of cognitive agency. NeuroImage, 31(2):896-905.

Minzenberg, M.M., Poole, J.H., Fenton, C., Vinogradov, S. (2004). Association of anticholinergic load with impairment of complex attention and memory in schizophrenia. American Journal of Psychiatry, 161:116-24.

Pegues, M.P., Rogers, L.J., Amend, D., Vinogradov, S., Deicken, R.F. (2003). Anterior hippocampal volume reduction in male patients with schizophrenia. Schizophrenia Research, 1:105-15.

Minzenberg, M., Poole, J.H., Ober, B.A., Shenaut, G.K., Vinogradov, S. (2003). Slowed lexical processing is uniquely associated with positive and disorganized symptoms in schizophrenia. Cognitive Neuropsychiatry, 8:107-127.

Marco, E.J., Wolkowitz, O.M., Vinogradov, S., Poole, J.H., Lichtmacher, J., Reus, V.I. (2002). Double-blind antiglucocorticoid augmentation in schizophrenia and schizoaffective disorder. World Journal of Biological Psychiatry, 3:156-161.

Faculty: Owen Wolkowitz, M.D.
Owen Wolkowitz, M.D. is a Professor in the Department of Psychiatry; he collaborates with Dr. Victor Reus, another TRC mentor. Dr. Wolkowitz's main scientific interests lie in the biological mechanisms by which stress can lead to depression and substance abuse, as well as the biological sequellae of stress, depression and co-morbid substance abuse. Specific research foci are clinical trials (in normals, depressives and individuals at-risk for alcoholism or substance abuse) examining steroid and neurosteroid hormones (cortisol, DHEA, allopregnanolone), neurotrophic factors (brain-derived neurotrophic factor, BDNF) and markers of cellular aging. A current clinical study, funded by NIAAA, is examining the role of allopregnanolone (a GABA receptor stimulating neurosteroid) in mediating the reinforcing effects of alcohol, and the ability of other hormones (pregnenolone) to antagonize alcohol's effects. He teaches clinical psychopharmacology to UCSF's psychiatry residents, has published over 150 scientific articles and has mentored 40 students or post-docs.

Harris D, Wolkowitz OM, Reus VI. (2005). Psychoneuroendocrinology. In: Sadock BJ, Sadock VA (eds), Kaplan & Sadock's Comprehensive Textbook of Psychiatry, 8th ed. Philadelphia, Lippincott Williams & Wilkins,pp. 126-136.

Meieran S, Reus VI, Webster R, Shafton R, Wolkowitz OM. (2004). Chronic pregnenolone effects in normal humans: Attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology, 29, 486-500.

Wolkowitz OM, Reus VI. (2003). Neurotransmitters, neurosteroids and neurotrophins: new models of the pathlophysiolgy and treatment of depression. World Journal of Biological Psychiatry. 4, 98-102.

Wolkowitz OM, Rothschild AJ (eds.) (2003). Psychoneuroendocrinology: The Scientific Basis of Clinical Practice. Washington, DC, American Psychiatric Press, Inc.

Harris DS, Reus VI, Wolkowitz OM, Mendelson JE, Jones RT. (2003). Altering cortisol level does not change the pleasurable effects of methamphetamine in humans. Neuropsychopharmacology. 28, 1677-84.

Faculty: Kristine Yaffe, M.D.
Kristine Yaffe, M.D. is an Associate Professor in the Departments of Psychiatry, Neurology and Epidemiology at the University of California, San Francisco (UCSF). She also is Chief of Geriatric Psychiatry and Director of the Memory Disorders Clinic at the San Francisco VA Medical Center. In both her research and in her clinical work, she has directed her efforts towards improving the care of patients with cognitive disorders and other geriatric neuropsychiatric conditions. Dr. Yaffe's research has focused on the predictors of cognitive decline and dementia in older adults. She is particularly interested in identifying novel strategies to prevent cognitive decline. One of her research focuses is examining how estrogen and other hormones influence cognitive function and depression. Dr. Yaffe is also focusing on multi-ethnic populations of elders in order to determine if identified predictors of cognitive decline vary amongst different ethnic groups. Dr. Yaffe recently co-chaired the NIH sponsored workshop on Healthy Brain Aging. Her work is funded by the NIH, the Paul Beeson Faculty Scholars in Aging Program and NARSAD.

Barnes D, Alexopolous G, Lopez O, Williamsen J, Yaffe K. (2006). Depressive symptoms, vascular disease, and mild cognitive impairment: Findings from the cardiovascular health study. Archives of General Psychiatry, 63:273-79.

Sink K, Holden K, Yaffe K. (2005). Pharmacological treatment of neuropsychiatric symptoms of dementia: A review of the evidence. JAMA, 293:596-608.

Whitmer R, Gunderson E, Barrett-Connor E, Quesenberry C, Yaffe K. (2005). Obesity in middle age and future risk of dementia: A 27 year longitudinal population based study. British Medical Journal, 330:1360-4.

Yaffe K, Kreuger K, Cummings S, Blackwell T, Henderson V, Sarkar S, Ensrud K, Grady D. Effect of raloxifene on prevention of dementia and cognitive impairment in older women: The multiple outcomes of raloxifene evaluation (MORE) randomized trial. American Journal of Psychiatry, 162:683-690.

Yaffe K, Kanaya A, Lindquist, K, Simonsick E, Harris T, Shorr R, Tylavsky F, Newman A. (2005). Metabolic syndrome, inflammation and cognitive decline. JAMA, 292:2237-2242.